UN Secretary-General Antonio Guterres is deeply disturbed by the destruction of a high-rise building in Gaza City, by an Israeli airstrike, that housed the offices of several international media organizations, said Stephan Dujarric, Spokesperson for the Secretary-General in a statement on Sunday.

In a statement, Dujarric said added that "The Secretary-General is dismayed by the increasing number of civilian casualties, including the death of ten members of the same family, including children, as a result of an Israeli airstrike last night in the al-Shati camp in Gaza, purportedly aimed at a Hamas leader,"

"The Secretary-General reminds all sides that any indiscriminate targeting of civilians and media structures violates international law and must be avoided at all costs," the spokesperson said.

Israeli air and artillery strikes on Gaza since Monday have killed 145 people including 41 children, and wounded another 1,100, health officials say, the worst violence in the region since 2014.

Palestinian armed groups have fired at least 2,300 rockets at Israel, killing 10 people, including a child and a soldier, and wounding over 560 Israelis. Israeli air defenses have intercepted many rockets.

US Secretary for Israel-Palestinian Affairs Hady Amr was to hold talks Sunday with Israeli leaders before meeting Palestinian officials to seek a "sustainable calm," the State Department said.

The situation on the border between Israel and the Palestinian Gaza Strip has been deteriorating for the last week. Earlier this month, the escalation of the Israeli-Palestinian conflict started when the unrest began in East Jerusalem over an Israeli court's decision to evict several Palestinian families from the area.

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