During the pandemic, the terror of COVID-19 transformed hand sanitizers from a simple hygiene product into a vital weapon against the virus. This led to a noticeable increase in their usage and sales. Even as we have moved past the pandemic, the practice of frequent sanitiser use persists.

A recent study, conducted using human cell cultures and mice, revealed that chemicals found in everyday disinfectants, including those used in furniture, textiles, and adhesives, could potentially harm brain support cells during crucial stages of the organ’s growth.

Erin Cohn, a molecular biologist at Case Western Reserve University in Ohio, and his team examined 1,823 compounds of unknown toxicity. They identified two chemical types that either killed or halted the maturation of oligodendrocytes, a type of neurological support cell, in lab conditions.

Oligodendrocytes are responsible for insulating neurons, ensuring efficient signal transmission within the brain.

Hand sanitizers
Image : Times of India

Chemicals and Their Effects on Brain Cells

The researchers identified one of the two chemical classes as quaternary compounds, commonly found in wipes, hand sanitisers, disinfectant sprays, and personal care items like toothpaste and mouthwash. These compounds are used for their bacteria and virus-killing properties, and can be ingested or inhaled by users.

The second class of chemicals identified was organophosphates, which are used as flame retardants and are typically found in textiles, adhesives, and household items like electronics and furniture. These fat-soluble chemicals can be absorbed through the skin and reach the brain.

Experimental Findings on Mice

In experiments on mice, the animals were given an oral dose of one of three quaternary compounds. Days later, these chemicals were detectable in the brain tissue. The researchers also observed a decrease in the number of oligodendrocytes in the brains of the animals after administering ten daily doses of a quaternary compound known as cetylpyridinium chloride during a critical period of brain development.

Cohn concluded, “We discovered that oligodendrocytes, unlike other brain cells, are surprisingly susceptible to quaternary ammonium compounds and organophosphate flame retardants.”

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